Research team

Master Degree
Carine THIBAUD, Michael CORRIN, Estefania ECHEVERRY, Francois THERRIAULT-PROULX, Xiang Qun SHI

Ph.D.
Joel CREPEAU, Steven PRESCOTT, Benjamin SMITH, Jeffrey COULL, Nadège CHÉRY, Tak Pan WONG, Guillaume LAVERTU, Dominic BOUDREAU, Yoan LECHASSEUR, Antoine GODIN, Pascal DUFOUR, Harold DEHEZ, Cyril BORIES

Postdoctoral researcher
Sophie LAFFRAY, Charalampos LABRAKAKIS, Martin GAGNON, Santiago COSTANTINO, Jean-Pierre PARÉ, Matilde CORDERO-ERAUSQUIN, Carl BARTELS, Florence KELLER, Ji ZHANG, Gurgen MELKONYAN, Xiao-Hong YU, Jody SWIFT, Annie CASTONGUAY, Louis-Etienne LORENZO, Nicolas DOYON, Francesco FERRINI, Hélène BOURQUE

Research areas

spinal cord, sensory physiology, synaptic transmission, pain, electrophysiology, patch clamp, biophysics, cellular maging, fluorescence spectroscopy, nanoprobes

Scholarships and grants

April 2002 - March 2015 : Canadian Institutes of Health Research (CIHR), "NeuroPhysics: Setting New Frontiers in Neuroscience with Material Sciences, Photonics and Computational Sciences" (Principal investigator)

April 1995 - March 2013 : Canadian Institutes of Health Research (CIHR), "Plasticity of inhibition in spinal sensory pathways" (Principal investigator)

September 2008 - August 2012 : Canada Foundation for Innovation (CFI), "Probing Pain Pathways with Light: from Ionic Mechanisms to Therapeutics" (Principal investigator)

April 2007 - March 2011 : Fonds de la Recherche en Santé du Québec (FRSQ), "Quebec Pain Research Network" (Principal investigator)

April 1996 - March 2010 : Natural Sciences and Engineering Research Council of Canada (NSERC), "Modeling synapses and their impact on integrative properties of neurons" (Principal investigator)

October 2004 - September 2009 : Canadian Institutes of Health Research (CIHR), "Nanotools for Neuropharmacology" (Principal investigator)

July 2004 - June 2009 : Canadian Institutes of Health Research (CIHR), "CRULRG Microscopy/Imaging facility" (Principal investigator)

February 2003 - January 2009 : Canada Foundation for Innovation (CFI) & Gov. of Quebec, "Neurophotonics Centre" (Principal investigator)

November 2003 - October 2008 : National Institute on Ageing (NIA) (USA), "Synaptic Alterations in the Cerebral Cortex during Aging" (Co-investigator)

October 2004 - September 2008 : Neuroscience Canada, "Transforming Neuropathic Pain Research in Canada" (Co-investigator)

May 2004 - April 2008 : Networks of Centres of Excellence (NCE), "Improved femtosecond laser approaches for cellular imaging in live tissue" (Principal investigator)

July 2004 - March 2007 : Canadian Institutes of Health Research (CIHR), "Novel microprobes for combined optical and electrical recording in vivo" (Principal investigator)

January 2005 - March 2006 : Canadian Institutes of Health Research (CIHR), "Target directed discovery of compounds modulating intracellular chloride" (Principal investigator)

Recent publications

Inhibitory coupling between inhibitory interneurons in the spinal cord dorsal horn. C Labrakakis, LE Lorenzo, C Bories, A Ribeiro-da-Silva, Y De Koninck , Mol Pain (2009) , Volume 5 , pages 24

Pyramidal neurons switch from integrators in vitro to resonators under in vivo-like conditions. SA Prescott, S Ratté, Y De Koninck, TJ Sejnowski , J Neurophysiol (2008) , Volume 100 (Issue 6) , pages 3030-42

Biophysical basis for three distinct dynamical mechanisms of action potential initiation. SA Prescott, Y De Koninck, TJ Sejnowski , PLoS Comput Biol (2008) , Volume 4 (Issue 10) , pages e1000198

Postnatal changes in the Rexed lamination and markers of nociceptive afferents in the superficial dorsal horn of the rat. LE Lorenzo, M Ramien, M St Louis, Y De Koninck, A Ribeiro-da-Silva , J Comp Neurol (2008) , Volume 508 (Issue 4) , pages 592-604

Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Zhang, XQ Shi, S Echeverry, JS Mogil, Y De Koninck, S Rivest , J Neurosci (2007) , Volume 27 (Issue 45) , pages 12396-406

Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain. AF Keller, S Beggs, MW Salter, Y De Koninck , Mol Pain (2007) , Volume 3 , pages 27

Dendritic spine viscoelasticity and soft-glassy nature: balancing dynamic remodeling with structural stability. BA Smith, H Roy, P De Koninck, P Grutter, Y De Koninck , Biophys J (2007) , Volume 92 (Issue 4) , pages 1419-30

Altered chloride homeostasis in neurological disorders: a new target. Y De Koninck , Curr Opin Pharmacol (2007) , Volume 7 (Issue 1) , pages 93-9

Two-photon excitation fluorescence microscopy with a high depth of field using an axicon. P Dufour, M Piché, Y De Koninck, N McCarthy , Appl Opt (2006) , Volume 45 (Issue 36) , pages 9246-52

Reduction of anion reversal potential subverts the inhibitory control of firing rate in spinal lamina I neurons: towards a biophysical basis for neuropathic pain. SA Prescott, TJ Sejnowski, Y De Koninck , Mol Pain (2006) , Volume 2 , pages 32

Microscopie à deux photons pour l’imagerie cellulaire fonctionnelle : avantages et enjeux ou "un photon c’est bien … mais deux c’est mieux!". P Dufour, S Dufour, A Castonguay, N McCarthy, Y De Koninck , Med Sci (Paris) (2006) , Volume 22 (Issue 10) , pages 837-44

Nonlinear interaction between shunting and adaptation controls a switch between integration and coincidence detection in pyramidal neurons. SA Prescott, S Ratte, Y De Koninck, TJ Sejnowski , J Neurosci (2006) , Volume 26 (Issue 36) , pages 9084-97

Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J Zhang, Y De Koninck , J Neurochem (2006) , Volume 97 (Issue 3) , pages 772-83

Imbalance towards inhibition as a substrate of aging-associated cognitive impairment. TP Wong, G Marchese, MA Casu, A Ribeiro-da-Silva, AC Cuello, Y De Koninck , Neurosci Lett (2006) , Volume 397 (Issue 1-2) , pages 64-8

Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia. TJ Price, F Cervero, Y de Koninck , Curr Top Med Chem (2005) , Volume 5 (Issue 6) , pages 547-55

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. JA Coull, S Beggs, D Boudreau, D Boivin, M Tsuda, K Inoue, C Gravel, MW Salter, Y De Koninck , Nature (2005) , Volume 438 (Issue 7070) , pages 1017-21

Destruction of polymer growth substrates for cell cultures in two-photon microscopy. C Thibaud, V Koubassov, P De Koninck, SL Chin, Y De Koninck , J Microsc (2005) , Volume 220 (Issue Pt 2) , pages 120-7

Differential maturation of GABA action and anion reversal potential in spinal lamina I neurons: impact of chloride extrusion capacity. M Cordero-Erausquin, JA Coull, D Boudreau, M Rolland, Y De Koninck , J Neurosci (2005) , Volume 25 (Issue 42) , pages 9613-23

Morphology and neurokinin 1 receptor expression of spinothalamic lamina I neurons in the rat spinal cord. XH Yu, A Ribeiro-da-Silva, Y De Koninck , J Comp Neurol (2005) , Volume 491 (Issue 1) , pages 56-68

Integration time in a subset of spinal lamina I neurons is lengthened by sodium and calcium currents acting synergistically to prolong subthreshold depolarization. SA Prescott, Y De Koninck , J Neurosci (2005) , Volume 25 (Issue 19) , pages 4743-54

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