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Cellular and Molecular Neuroscience Research Axis

Dr. Yves De Koninck

Professor of Psychiatry & Neuroscience, Laval University
Scientific Director of the Quebec Mental Health Institute Research Center (CRIUSMQ)

CRIUSMQ
2601, Chemin de la Canardière
Bureau F-6500

Québec (Québec) G1J 2G3
Canada

Tel. : (418) 663-5747 ext. 6885
Fax. : (418) 948-9030

yves.dekoninck@crulrg.ulaval.ca

Research team

Ph.D.
Jimena PEREZ-SANCHEZ, Isabel PLASENCIA, Dominic BOUDREAU, Louis THIBON, Gabrielle THERIAULT

Postdoctoral researcher
Louis-Etienne LORENZO, Marc BERGERON, Charles-Antoine LAMONTAGNE, Cyril BORIES, Martin COTTET, Erik BELANGER, Feng WANG, Robert BONIN

Past students

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Research areas

Spinal cord, Sensory physiology, Synaptic transmission and plasticity, Pain, Membrane biophysics, Ion channels, GABA. Glycine, Inhibition, Glutamate, Excitation

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Illnesses under study

Chronic pain, Multiple sclerosis, Cognitive decline in aging, Alzheimer's disease

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Technology

Electrophysiology (in vitro and in vivo), Patch clamp, Cellular imaging, Fluorescence spectroscopy, Non-linear microscopy, In vivo and in vitro optogenetics, Nanoprobes, Noise analysis, Computer simulaitons

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Projects

Global description

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Scholarships and grants

Avril 2014 - Août 2017 : International Human Frontier Science Program Organization, "Probing & controlling single neuron synaptic function in the brain with light, intrabodies & sensors" (Principal investigator)

Avril 2014 - Mars 2017 : CIRH, "Sensing and modulating neuronal activity from the spinal epidural space with optical fibers" (Co-investigator)

Décembre 2013 - Décembre 2019 : Fondation de l'Université Laval, "Chaire de recherche cerveau et douleur" (Principal investigator)

Avril 2012 - Mars 2015 : Fonds de recherche du Québec - Santé, "Douleur chronique et maladies mentales : nouvelles technologies pour l'identification et la validation de cibles thérapeutiques par dissection optique" (Principal investigator)

Avril 2011 - Mars 2017 : Fonds de recherche du Québec - Nature et technologies, "Centre d'optique, photonique et laser (COPL)" (Co-investigator)

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Recent publications

"A spinal analog of memory reconsolidation enables reversal of hyperalgesia." , Bonin RP, De Koninck Y. , Nat Neurosci. 2014 Jul 6. (2014)

"KCC2: a new therapeutical target for the treatment of neurological diseases (article in French)." , Bergeron MJ, Castonguay A, De Koninck Y. , Med Sci (Paris). 2014 May;30(5):514-7. (2014)

"Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite the Presence of GABAA Receptors." , Lorenzo LE, Godin AG, Wang F, St-Louis M, Carbonetto S, Wiseman PW, Ribeiro-da-Silva A, De Koninck Y. , J Neurosci. 2014 Jun 11;34(24):8300-17. (2014)

"Extended two-photon microscopy in live samples with Bessel beams: steadier focus, faster volume scans, and simpler stereoscopic imaging." ,

Thériault G, Cottet M, Castonguay A, McCarthy N, De Koninck Y.

, Front Cell Neurosci. 2014 May 20;8:139. (2014)

A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments. Bonin RP, Bories C, De Koninck Y. , Mol Pain. 2014 Apr 16;10(1):26. (2014)

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